This makes overdose way more probable; hence, combining central nervous procedure depressant drugs is incredibly dangerous.

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pentobarbital will lower the level or influence of cyclosporine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

pentobarbital will lower the extent or impact of loratadine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.

pentobarbital will lessen the extent or effect of piroxicam by influencing hepatic enzyme CYP2C9/ten metabolism. Slight/Significance Unidentified.

pentobarbital will reduce the level or result of ramelteon by impacting hepatic enzyme CYP2C9/10 metabolism. Slight/Importance Unfamiliar.

pentobarbital will decrease the extent or result of zaleplon by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unknown.

pentobarbital will lessen the level or outcome of nateglinide by impacting get more info hepatic enzyme CYP2C9/10 metabolism. Use Warning/Keep track of.

pentobarbital will lower the extent or effect of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Outcome of coadministering a solid CYP3A4 inducer with fedratinib hasn't been examined.

pentobarbital will reduce the extent or result of nitrendipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known.

pentobarbital will increase toxicity of methoxyflurane by raising metabolism. Contraindicated. Increased metabolism of methoxyflurane to nephrotoxic compounds.

pentobarbital will lessen the extent or influence of donepezil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Mysterious.

pentobarbital will lessen the extent or effect of lapatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.

pentobarbital will decrease the level or result of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Powerful CYP3A4 inducers may possibly lessen suvorexant efficacy; if amplified suvorexant dose required, don't exceed 20 mg/day